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Patients should be informed about the potential benefits and risks of corticosteroid therapy and should participate in treatment decisions. Patients who have a chronic or recurrent allergic disorder should undergo evaluation periodically regarding risk of allergy, which may be influenced by the presence of allergy-related clinical signs. Patients with any of the following clinical signs have an increased risk of allergic reactivity: Sinus inflammation Aging (age > 50) / Corticosteroid therapy (dose > 60 mg/mo) A history of corticosteroid therapy (or corticosteroids) Precancerous lesions / Any type of chronic asthma Diarrhea and bloating An increased likelihood of developing asthma or hay fever History of allergy Symptoms suggestive of a medical infection or severe allergic skin disease A history of allergy or exposure to the active ingredients in corticosteroids, including cortisone, cefuroxime, dimethylglycine, or diphenhydramine Patients should not be given corticosteroids unless proven to be safe to do so by clinical evaluation, and can have their treatment discontinued if a treatment-emergent adverse event (TEAE) occurs. All patients should follow the protocol to monitor for exacerbations (repetitive symptoms of corticosteroid exposure) (Figure 1). A TEAE should be reported to the local health professional(s) upon discovery of a patient's worsening condition. If a patient reports worsening of symptoms while undergoing corticosteroid therapy, the dose, duration, and frequency of therapy will be increased (see Table). Table 1. Dose and Frequency of Dosing of Corticosteroids. Dose Doses of therapy Duration Number of injections 12-15 10-18 Number of times per day 12-15 14-17 Frequency (for the first few days) of injections 12-15 4-5 Frequency (for the course of therapy) 12-15 4-5 Frequency (for the course of therapy) 3 12-16-48 Days for first injection 12-15 3-4 Days for 1 injection (in each dose) 12-15 1-2 Days for 2 injections (in each dose) 12-16-48 The patient's healthcare provider can monitor the efficacy of corticosteroid therapy by determining the ratio of the overall body weight change to change in the steroid-treated group at any time during the course of treatment as follows: Table 2. Treatment of the Treatment-Emergent, Emergent, Related Article: